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We investigate the molecular basis of insulin signal transduction to understand the pathophysiology of diabetes and its related disorders, including obesity and infertility; cardiovascular and vascular disease; retinal disease; and the regulation of life-span. Our studies of the insulin-signaling network reveal common elements that promote peripheral insulin action, pancreatic beta-cell growth and function, and hypothalamic control of nutrient homeostasis and fertility. Our work also relates to brain diseases such Alzheimer and Huntington's. Certain forms of cancer might be understood through our work. Our immediate goal is to reveal new strategies to treat dysregulated nutrient metabolism that progresses to diabetes and dementia, and reduces life-span.
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